The Structural Genomics Consortium at the University of Toronto (SGC-Toronto) collaborates widely locally and globally to support breakthrough research - creating protein-focused open science tools, knowledge, and reagents to enable drug discovery. The SGC-Toronto has a team of more than 50 trainees, researchers and support staff working in approximately 14,000 square feet of research space on discovery projects in the areas of chemical probes, structural biology, bioinformatics, molecular biophysics, cellular assays, and chemical biology and target discovery.

Ongoing projects involve: 

1. The characterization of human and viral proteins using structural biology, biophysics and chemical biology, addressing human health and diseases such as cancer, neurodegeneration, inflammation, human fertility, viral infection and rare diseases.   
2. Use of state-of-the-art methodologies, such as semi-automated high throughput protein production and assays, and structure-guided development of novel chemical probes (tool compounds).
3. Development of new tools to study human health and disease with new drug modalities, such as PROTACs (Targeted Protein Degradation) and other forms of proximity pharmacology.
4. Generating protein-ligand datasets to support the development of machine learning and artificial intelligence algorithms in hit-finding, and supporting organized benchmarking these algorithms by providing experimental testing of predictions. 

The wet lab at SGC Toronto is equipped with state-of-the-art infrastructure to support protein production, protein biophysics, proteins structure capabilities (crystallography, NMR and cryoEM), molecular biology, and cell and tissue culture.The SGC-Toronto laboratory, under the direction of Professor Cheryl Arrowsmith, operates within the Temerty Faculty of Medicine at the University of Toronto and is located in the MaRS Discovery District, at the heart of Toronto. Scientists at the SGC-Toronto are affiliated with several University Departments including the Departments of Medical Biophysics, Pharmacology and Toxicology, Molecular Genetics and Chemistry.